Prof. Amos Oppenheim

Professor

Bio:
B.Sc. 1962, U.C. Davis; Ph.D. 1966, U.C. Davis; Visiting Research Fellow, Pasteur Institute, Paris 1968-1970; Visiting scientist, National Cancer Institute, Lab of Molecular Biology, 1976-1977; Visiting scientist, National Cancer Institute, spring 1979; Visiting scientist, Friedrich Meischer Institute, Basel, Summer 1979; Visiting scientist, National Institutes of Health, National Cancer Institute, Lab of Molecular Biology, 1980-1981; Visiting scientist, National Institutes of Health, National Cancer Institute, summers 1982, 1985, Visiting Professor, The Cancer Institute, Columbia University, New York, Summers 1986, 1990.

Head of Israeli National Node of European Molecular Biology Data Network Steering Committee, Head of Authority for Graduate Studies at the Hebrew University; Head of the Biotechnology Teaching Program at the Hebrew University.

Research Interests:
Regulation of gene expression in bacteria and bacteriophage, structure function reationships in macromolecules, biotechnology of gene expression in bacteria, biocontrol of plant pathogens by genetic engineering

Recent Publications:

1. Functional and structural elements of the mRNA of the cIII gene of bacteriophage lambda. Altuvia S, Kornitzer D, Koby S and Oppenheim AB. J.Mol.Biol. 218, 723-733 (1991).
2. The activity of the CIII regulator of lambdoid bacteriophages resides within a 24 amino acid protein domain. Kornitzer D, Altuvia S and Oppenheim AB. Proc.Natl.Acad.Sci. 88, 5217-5221 (1991).
3. Supercoiling, integration host factor and a dual promoter system, participates in the control of the bacteriophage ( pL promoter. Giladi H, Koby S, Gottesman ME and Oppenheim AB. J.Mol.Biol. 224, 937-948 (1992).
4. Genetic and biochemical analysis of the integration host factor of Escherichia coli. Mengritsky G, Goldenberg D, Mendelson I, Giladi H and Oppenheim AB. J.Mol.Biol. 231, 646-657 (1993).
5. Integration host factor binds to a unique class of complex repetetive extragenic DNA sequences in Escherichia coli. Oppenheim AB, Rudd KE, Mendelson I and Teff D. Mol.Microbiol. 10, 113-122 (1993).
6. Crystal structure of a bacterial chitinase at 2.3 A resolution. Perrakis A, Tews I, Dauter Z , Oppenheim AB, Chet I, Wilson KS and Vorgias CE. Structure 2, 1169-1180 (1994).
7. Enhanced activity of the bacteriophage ( PL promoter at low temperature. Giladi H, Goldenberg D, Koby S and Oppenheim AB. Proc.Natl.Acad.Sci. 92, 2184-2188 (1995).
8. Escherichia coli FtsH is a membrane-bound, ATP-dependent protease which degrades the heat-shock transcription factor (32. Tomoyasu T, Gamer J, Bukau B, Kanemori M, Mori H, Rutman AJ, OppenheimAB, Yura T, Yamanaka K, Niki H, Higura S and Ogura T. EMBO J 14, 2552- 2560 (1995).
9. Differential mRNA stability of the cspA gene in the cold shock response of Escherichia coli Goldenberg D, Azar I and Oppenheim AB. Mol.Microbiol.19, 241-248 (1996).
10. Bacterial chitobiase structure provides insight into catalytic mechanism and the basis of Tay-Sachs disease. Tews I, Perrakis A, Oppenheim A, Dauter Z, Wilson, KS and Vorgias CE. Nature Structural Biology 3, 638-648 (1996).
11. Identification of an UP element within the IHF binding site at th pL1- pL2 tandem promoter of bacteriophage (. Giladi H, Murakami K, Ishihama A and Oppenheim AB. J.Mol.Biol. 260, 484-491(1996).

Email:
ao@cc.huji.ac.il

Phone:
Telephone: 972-2-6757309, 6758642/3
Fax: 972-2-6757308

1.	Functional and structural elements of the mRNA of the cIII gene of bacteriophage lambda. Altuvia S, Kornitzer D, Koby S and Oppenheim AB. J.Mol.Biol. 218, 723-733 (1991).
2.	The activity of the CIII regulator of lambdoid bacteriophages resides within a 24 amino acid protein domain. Kornitzer D, Altuvia S and Oppenheim AB. Proc.Natl.Acad.Sci. 88, 5217-5221 (1991).
3.	Supercoiling, integration host factor and a dual promoter system, participates in the control of the bacteriophage ( pL promoter. Giladi H, Koby S, Gottesman ME and Oppenheim AB. J.Mol.Biol. 224, 937-948 (1992).
4.	Genetic and biochemical analysis of the integration host factor of Escherichia coli. Mengritsky G, Goldenberg D, Mendelson I, Giladi H and Oppenheim AB. J.Mol.Biol. 231, 646-657 (1993).
5.	Integration host factor binds to a unique class of complex repetetive extragenic DNA sequences in Escherichia coli. Oppenheim AB, Rudd KE, Mendelson I and Teff D. Mol.Microbiol. 10, 113-122 (1993).
6.	Crystal structure of a bacterial chitinase at 2.3 A resolution. Perrakis A, Tews I, Dauter Z , Oppenheim AB, Chet I, Wilson KS and Vorgias CE. Structure 2, 1169-1180 (1994).
7.	Enhanced activity of the bacteriophage ( PL promoter at low temperature. Giladi H, Goldenberg D, Koby S and Oppenheim AB. Proc.Natl.Acad.Sci. 92, 2184-2188 (1995).
8.	Escherichia coli FtsH is a membrane-bound, ATP-dependent protease which degrades the heat-shock transcription factor (32. Tomoyasu T, Gamer J, Bukau B, Kanemori M, Mori H, Rutman AJ, OppenheimAB, Yura T, Yamanaka K, Niki H, Higura S and Ogura T. EMBO J 14, 2552- 2560 (1995).
9.	Differential mRNA stability of the cspA gene in the cold shock response of Escherichia coli Goldenberg D, Azar I and Oppenheim AB. Mol.Microbiol.19, 241-248 (1996).
10.	Bacterial chitobiase structure provides insight into catalytic mechanism and the basis of Tay-Sachs disease. Tews I, Perrakis A, Oppenheim A, Dauter Z, Wilson, KS and Vorgias CE. Nature Structural Biology 3, 638-648 (1996).
11.	Identification of an UP element within the IHF binding site at th pL1- pL2 tandem promoter of bacteriophage (. Giladi H, Murakami K, Ishihama A and Oppenheim AB. J.Mol.Biol. 260, 484-491(1996).